14-Title: In silico analysis of interferon-γ from different animals
Authors: Amit Kumar Pandey, Bijay Kumar Chaudhari, Pankaj Kumar Maurya
Source: Ruminant Science (2012)-1(2):157-160.
How to cite this manuscript: Pandey Amit Kumar, Chaudhari Bijay Kumar and Maurya Pankaj Kumar (2012). In silico analysis of interferon-γ from different animals. Ruminant Science 1(2):157-160.
Interferon γ is a type II class interferon, and critical for innate and adaptive immunity against viral and intracellular bacterial infections and for tumor control. It is produced by natural killer (NK) cells and by CD4 Th1 and CD8 cytotoxic lymphocytes. It acts by JAK-STAT pathway, promotes NK cell activity, antigen presentation and iNOS production. The in silico analysis of nucleotide and protein sequence facilitates cloning and expression of the IFNγ and help in understanding the phylogeny of the protein.
Ank N, West H and Paludan SR (2006). IFN-lambda: Novel Antiviral Cytokines. Journal Interferon Cytokine Research 26:373-379.
Ealick SE, Cook WJ and Vijay-Kumar S (1991). Three-dimensional structure of recombinant human interferon gamma. Science 252:698-702.
Isaacs A and Lindenmann, J (1957). Virus interference. I. The Interferon. Proceedings of the Royal Society B: Biological Sciences 147:258–267.
Onoguchi K, Yoneyama M, Takemura A, Akira S, Taniguchi T, Namiki H and Fujita T (2007). Viral infections activate types I and III Interferon genes through a common mechanism. Journal of Biological Chemistry 282:7576-7581.
Sen GC (2001). Viruses and interferons. Annual Review of Microbiology 55:255-281.
Subramaniam PS, Torres BA and Johnson HM (2001). So many ligands, so few transcription factors: a new paradigm for signaling through the STAT transcription factors. Cytokine 15:175-187.
Uze G and Monneron D (2007). IL-28 and IL-29: Newcomers to the Interferon family. Biochimie 89:729-734.