22-Title: Therapeutic evaluation of ascorbic acid and manganese chloride as antioxidants during diaphragmatic herniorrhaphy in buffaloes
Authors: KN Joshi, PB Patel, BN Suthar, BJ Patel, JJ Parmar and MS Gami
Source: Ruminant Science (2014)-3(2):237-239
How to cite this manuscript: Joshi KN, Patel PB, Suthar BN, Patel BJ, Parmar JJ and Gami MS (2014). Therapeutic evaluation of ascorbic acid and manganese chloride as antioxidants during diaphragmatic herniorrhaphy in buffaloes. Ruminant Science 3(2):237-239.
The present study was conducted on 12 clinical cases of diaphragmatic hernia in buffaloes. The study was conducted in 2 groups; viz. Group-I (n=6) in which animals were given ascorbic acid @ 5 g (total dose) and in Group-II (n=6) Manganese chloride (MnCl2) was administered @ 5 mg/kg body weight in one litre of normal saline solution (NSS) intravenously. Blood samples were used for estimation of malondialdehyde (MDA) and superoxide dismutase (SOD) in erythrocytes immediately after the collection prior to herniorrhaphy (at 24 hours) and then at 48, 72 and 96 hours after rumenotomy prior to rumenotomy and prior to herniorrhaphy (at 24 hours) and then at 48, 72 and 96 hours after rumenotomy. Ascorbic acid @ 5 g (total dose) intravenously compared to MnCl2 (@ 5 mg/kg body weight intravenously) before and after rumenotomy (at 24, 48, 72 and 96 hour post operative) more efficiently ameliorates the pre and post operative oxidative stress.
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