Influence of meloxicam on pharmacokinetic alterations of moxifloxacin in male goats

24-Title: Influence of meloxicam on pharmacokinetic alterations of moxifloxacin in male goats

Authors: Nilesh R Rathod, Swapnil V Kukade, Milindmitra K Lonare and Sunil W Hajare

Source: Ruminant Science (2015)-4(1):103-108.

How to cite this manuscript: Rathod Nilesh R, Kukade Swapnil V, Lonare Milindmitra K and Hajare Sunil W (2015). Influence of meloxicam on pharmacokinetic alterations of moxifloxacin in male goats. Ruminant Science 4(1):103-108.

Abstract

Combinational use of anti-microbial and anti-inflammatory agents in veterinary practice is very common, thus there are every chances of alteration of pharmacokinetics of each other. The present study was carried out to investigate the effect of meloxicam on pharmacokinetic of moxifloxacin in male berari goats of vidarbha region of Maharashtra. For this purpose, single intramuscular dose of moxifloxacin (5 mg/kg) was administered alone and concomitantly with meloxicam (0.5 mg/kg IM). The plasma drug concentration of moxifloxacin was assayed by microbiological assay (ATCC-25922TM) at different time interval. The mean peak plasma concentration (Cmax) of moxifloxacin following its single dose administration and in co-administration with meloxicam in male goats was 18.77 ± 0.30 and 14.70±0.42 mg ml-1, and time required to attain the peak concentration (Tmax) was 3.33±0.42 and 1.33 ± 0.21 h, respectively. The elimination half-life (t½) and elimination rate () were not significantly altered in meloxicam co-treated male goats as compared with moxifloxacin alone treated group. Apparent volume of distribution area (Vd (area)) and total body clearance (CLB), of moxifloxacin were significantly higher (P< 0.01) in meloxicam concomitant administered goats. Results of present investigation conclude that administration of meloxicam during the treatment along with moxifloxacin can alter the disposition kinetics of moxifloxacin in berari goats.

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