Ruminant Science (2020) 9(1)

1-Title: Histological and immune-histochemical evaluation of ovarian cysts in cattle

Authors: Nora Mimoune, Mohammed Hocine Benaissa, Ratiba Baazizi, Saidi Radhwane, Azzouz Mohamed Yassine, Belarbi Ayed and Kaidi Rachid

Source: Ruminant Science (2020)-9(1):1-6.

How to cite this manuscript: Mimoune Nora, Benaissa Mohammed Hocine, Baazizi Ratiba, Radhwane Saidi, Yassine Azzouz Mohamed, Ayed Belarbi and Rachid Kaidi (2020). Histological and immune-histochemical evaluation of ovarian cysts in cattle. Ruminant Science 9(1):1-6.

Abstract

The present work aimed to determine the specific cellular localisation via immunohistochemistry of some factors (VEGF, Bcl, vimentin, Bax, Cyclin D1) that may be involved in the formation and/or persistence of ovarian cysts (OC) in cattle. A total of 300 ovaries were collected and evaluated by histological and immunohistochemical studies. OC showed strong positive reactions with vimentin, inhibin á subunit, VEGF and Bcl-2 antibodies in cystic walls. It is concluded that the abnormal changes in the expression of some intraovarian regulators might lead to follicle dysfunction and the cyst formation in cattle.

References

Baravalle C, Salvetti NR, Mira GA, Lorente JA and Ortega HH (2007). The role of ACTH in the pathogenesis of polycystic ovarian syndrome in rats: Hormonal profiles and ovarian morphology. Physiological Research 56:67-78.

Braw-Tal R, Pen S and Roth Z (2009). Ovarian cysts in high-yielding dairy cows. Theriogenology 72:690-698.

Choe C, Cho YW, Kim CW, Son DS, Han J and Kang D (2010). Identification of differentially expressed genes in bovine follicular cystic ovaries. Korean Journal of Physiology and Pharmacology 14:265-272.

Choudhary Ratan K, Pathak Devendra, Deka Dipak and Ramneek (2013). Vimentin identifies myoepithelial cells of buffalo mammary tissue. Ruminant Science 2(2):157-161.

Han L, Canjie W, Hasan R, Liya B, Jianguo C, Yanhong Z, Aizhein G and Liguo Y (2014). Characterization of the mechanism of inhibin alpha-subunit gene in mouse anterior pituitary cells by RNA interference. PLoS ONE 8(10):e74596.

Isobe N, Kitabayashi M and Yoshimura Y (2005). Microvascular distribution and vascular endothelial growth factor expression in bovine cystic follicles. Domestic Animal Endocrinology 29:634-645.

Isobe N and Yoshimura Y (2000). Immunocytochemical study of cell proliferation in the cystic ovarian follicles in cows. Theriogenology 54:1159-1169.

Kankhedia PC, Agrawal Manish, Mathur Manisha and Dadhich Hemant (2017). Histopathological observations on cystic ovarian conditions in sheep (Ovis aries). Ruminant Science 6(1):51-54.

Li W, Sun L, Chen S, Lu C, Liu Z, Hou X, Chen C, Han Y, Wang C, Li C and Zhou X (2015). Association of inhibin-alpha gene polymorphisms with follicular cysts in large white sows. Theriogenology 84(6):839-45.

Luna G Lee (1968). Manual of Histologic Staining Methods of the Armed Forces Institute of Pathology. 3rd Edn, McGraw-Hill, New York.

Mimoune Nora, Kaidi Rachid, Guedioura Abdelmoumène, Benaissa Mohamed Hocine and Azzouz Mohamed Yassine (2018). Characterization of ovarian follicular and cystic fluids in cows. Veterinaria 67:2.

Mimoune N, Baazizi R, Azzouz MY, Benaissa MH and Kaidi R (2019). Basic and new concepts of ovarian cyst pathogenesis in cattle. Veterinaria 68:2.

Monniaux D, Di Clemente N, Touzé JL, Belville C, Rico C, Bontoux M, Picard JY and Fabre S (2008). Intrafollicular steroids and anti-Müllerian hormone during normal and cystic ovarian follicular development in the cow. Biology of Reproduction 79:387-396.

Murayama C, Eiki Y, Akio M and Takashi S (2015). Effect in dedicator of cytokinesis 6 (DOCK6) on steroid production in theca cells of follicular cysts. Biochemical and Biophysical Research Communications 462:415-419.

Okuda K, Anna K, Masami S, Shuko M, Ryo N, Miki T, Izabela WP and Dariusz JS (2004). Progesterone is a suppressor of apoptosis in bovine luteal cells. Biology of Reproduction 71:2065-2071.

Rathore Anita, Dadhich H, Rani Sunita and Dadhich Rohitash (2016a). Pathological study on persistent corpus luteum in cattle. Ruminant Science 5(1):67-68.

Rathore Anita, Dadhich Hemant, Rani Sunita and Dadhich Rohitash (2016b). Pathology of adenomyosis in the female genital tract of cattle. Ruminant Science 5(2):263-264.

Rathore Anita, Dadhich Hemant and Rani Sunita (2018).Occurrence and pathomorphology of follicular cyst in the female genital tract of cattle. Ruminant Science 7(1):149-150.

Salvetti NR, Stangaferro ML, Palomar MM, Alfaro NS, Rey F, Gimeno EJ and Ortega HH (2010). Cell proliferation and survival mechanisms underlying the abnormal persistence of follicular cysts in bovines with cystic ovarian disease induced by ACTH. Animal Reproduction Science 122:98-110.

Shimizu T and Miyamoto A (2007). Progesterone induces the expression of vascular endothelial growth factor (VEGF) 120 and Flk-1, its receptor, in bovine granulosa cells. Animal Reproduction Science 102:228-237.

Stangaferro ML, Matiller V, Díaz PU, Ortega HH, Rey F, Rodríguez FM, Silva MA and Salvetti NR (2014). Role of activin, inhibin, and follistatin in the pathogenesis of bovine cystic ovarian disease. Animal Reproduction Science 148:97-108.

Todoroki J and Kaneko H (2006). Formation of follicular cysts in cattle and therapeutic effects of controlled internal drug release. Journal of Reproduction and Development 52(1):1-11.

Townson DH and Combelles CMH (2012). Ovarian follicular atresia. In: Basic Gynecology-Some Related Issues. Eds: Atef Darwish, InTech Publications, Shanghai, China pp 43-76. Available from: http://www.intechopen.com