Pharmacokinetics and bioavailability of long acting moxifloxacin in goats

Pharmacokinetics and bioavailability of long acting moxifloxacin in goats

Title: Pharmacokinetics and bioavailability of long acting moxifloxacin in goats

Authors: Anjana Kumari, RK Nirala, Archana Kumari and SK Mody  

Source: Ruminant Science (2017)-6(2):283-285.

Cite this reference as: Kumari Anjana, Nirala RK, Kumari Archana and Mody SK (2017). Pharmacokinetics and bioavailability of long acting moxifloxacin in goats. Ruminant Science 6(2):283-285.

  

Abstract

Moxifloxacin is a new enantiomerically pure, fourth generation fluoroquinolone that has potent antimicrobial activity against both Gram-negative and Gram-positive bacteria, anaerobes and atypical organisms. Present study was planned to investigate the pharmacokinetics of long acting moxifloxacin given by Intravenous (IV) and Intramuscular (IM) routes at the dose rate of 7.5 mg.kg-1 in six male Mehsana goats. Long Acting (LA) Moxifloxacin was injected intramuscularly and intravenously after that periodically blood samples were collected from jugular vein at different time interval up to 96 h post administration of drug. LA Moxifloxacin concentrations were determined by HPLC system with florescence detector.  After IV administration  the values of  different pharmacokinetic parameters viz; , t1/2, AUC, AUMC, ClB and MRT were 0.08 h-1, 9.43 h, 22.92  g.h.ml-1, 181.95 g.h2.ml-1, 0.33 L.h-1.kg-1 and 7.93 h, respectively. Following IM administration the values of different pharmacokinetic parameters like; t1/2, AUC, ClB and MRT were 15.19 h. 24.12 g.h-1ml, 0.31 L-1h-1kg and 15.62 h. The bioavailability was 107.97 percent. No adverse effects have been shown by the animals during experimental period. The calculated priming and maintenance doses of LA moxifloxacin are 8.6 and 7.4 mg.kg-1 (repeated at 48 h of interval), respectively to be given IM.

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