7-Title: HAEMATOBIOCHEMICAL STUDY OF PARATUBERCULOSIS IN GOATS (Capra hircus)
Authors: Anil Bittal, GP Jatav, Rashmi Choudhary, Nidhi Shrivastava, Supriya Shukla, AK Jayraw, Vivek Agrawal and Mukesh Shakya
Source: Ruminant Science (2025)-14(2):145-148.

Abstract

How to cite this manuscript: Bittal Anil, Jatav GP, Choudhary Rashmi, Shrivastava Nidhi, Shukla Supriya, Jayraw AK, Agrawal Vivek and Shakya Mukesh (2025). Haematobiochemical study of paratuberculosis in goats (Capra hircus). Ruminant Science 14(2):145-148.
Abstract
The present study focused on evaluating the haematological and biochemical alterations associated with paratuberculosis (pTB) in goats, caused by Mycobacterium avium subsp. paratuberculosis (MAP). A total of 250 goats, slaughtered at the Cantonment Board slaughterhouse, Dr Ambedkar Nagar (Mhow), were examined to identify MAP infections using faecal smear microscopy, impression smears and histopathological analysis. Special emphasis was placed on the hematobiochemical profiles of infected versus non-infected animals. Out of the 250 goats examined, MAP incidence was confirmed in 34.4% of cases through faecal smear examination. Goats with MAP infection exhibited marked alterations in haematological parameters. Affected animals showed significant anaemia, evident from reduced haemoglobin concentration, packed cell volume (PCV) and total erythrocyte count (TEC). In contrast, total leukocyte count (TLC) values were elevated, indicating a systemic inflammatory response. Biochemical assessments further revealed pronounced hypoproteinemia in MAP-infected goats, characterised by decreased total serum protein levels. Additionally, liver function tests revealed elevated levels of liver enzymes, including alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP), suggesting hepatic stress or damage potentially resulting from systemic effects of the chronic infection. These hematobiochemical alterations support the systemic impact of MAP beyond the gastrointestinal tract, even in cases where gross lesions are limited. The presence of anaemia and elevated liver enzymes in infected goats signifies the chronic and debilitating nature of the disease. The study revealed a significant reduction in values of haemoglobin, packed cell volume and total erythrocyte count with increased values of total leucocyte count along with significant hypoproteinaemia and elevated liver enzyme activities in goats infected with Mycobacterium avium subsp. paratuberculosis (MAP).
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