14-Title: In silico analysis of interferon-γ from different animals

Authors: Amit Kumar Pandey, Bijay Kumar Chaudhari, Pankaj Kumar Maurya

Source: Ruminant Science (2012)-1(2):157-160.

How to cite this manuscript: Pandey Amit Kumar, Chaudhari Bijay Kumar and Maurya Pankaj Kumar (2012). In silico analysis of interferon-γ from different animals. Ruminant Science 1(2):157-160.


Interferon γ is a type II class interferon, and critical for innate and adaptive immunity against viral and intracellular bacterial infections and for tumor control. It is produced by natural killer (NK) cells and by CD4 Th1 and CD8 cytotoxic lymphocytes. It acts by JAK-STAT pathway, promotes NK cell activity, antigen presentation and iNOS production. The in silico analysis of nucleotide and protein sequence facilitates cloning and expression of the IFNγ and help in understanding the phylogeny of the protein.


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