10-Title: Safety assessment of repeated intravenous ketoprofen administration based on hemato-biochemical alterations in sheep
Authors: SR Gondaliya, SK Bhavsar, RD Singh, JH Patel, RD Varia and AM Thaker
Source: Ruminant Science (2014)-3(2):181-184
How to cite this manuscript: Gondaliya SR, Bhavsar SK, Singh RD, Patel JH, Varia RD and Thaker AM (2014). Safety assessment of repeated intravenous ketoprofen administration based on hemato-biochemical alterations in sheep Ruminant Science 3(2):181-184.
Ketoprofen is a ‘non-selective cyclo-oxygenase inhibitor’ type of non-steroidal anti-inflammatory drug (NSAID) and used widely in the treatment of ruminants as anti-inflammatory, analgesic and antipyretic drug. The present investigation was undertaken to study impact of multiple doses of ketoprofen on hematological and biochemical parameters in sheep. Drug was administered intravenously at the dose rate of 3 mg/kg body weight in six Patanwadi sheep (weighing between 20 to 30 kg), repeated at 24 hours interval for 5 consecutive days. The mean values of hematological (hemoglobin, packed cell volume, total leukocyte count and differential leukocyte count) and biochemical parameters (serum alanine transaminase, alkaline phosphatase, acid phosphatase, lactate dehydrogenase, total bilirubin, serum creatinine, blood urea nitrogen, blood glucose, serum albumin and total protein) in treated animals do not differ significantly (p>0.05) when compared to pre-treatment (control) samples. Values of serum aspartate transaminase measured at 3rd, 4th and 5th day were found significantly lower than the control (0 day) but were remained within normal range. Mean values of blood urea nitrogen at 1st, 2nd, 3rd, 4th and 5th day differed significantly (p<0.05) when compared to control values, but clinically no abnormalities were noticed. Thus, it was suggested that monitoring of kidney functions should be appraised during long term ketoprofen therapy in sheep.
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