Title: Plasma leptin and biochemical profile around parturition in primiparous Sahiwal cows
Authors: Vijay Pandey, Rajesh Nigam, Rambachan, Pawanjit Singh, SP Singh and AK Madan
Source: Ruminant Science (2016)-5(2):227-233.
Cite this reference as: Pandey Vijay, Nigam Rajesh, Rambachan, Singh Pawanjit, Singh SP and Madan AK (2016). Plasma leptin and biochemical profile around parturition in primiparous Sahiwal cows. Ruminant Science 5(2):227-233.
Abstract
For studying the role of leptin hormone around parturition and to evaluate its association with other biochemical profile in high yielding primiparous Indian cow, six primiparous pregnant Sahiwal cows of same age group and body condition score were selected. The blood samples were collected from these cows on 30 day prepartum, day of parturition and on 30 day postpartum and plasma was harvested. The plasma samples were further analyzed for levels of leptin hormone, non-esterified fatty acids (NEFA), glucose, triglycerides (TG), cholesterol, high density lipoprotein (HDL), low density lipoprotein (LDL), total plasma protein (TPP), albumin, urea, creatinine, calcium (Ca), phosphorus (P) and potassium (K). The results of plasma leptin, TG, cholesterol, HDL and LDL showed highest level of leptin in late pregnancy (-30 days) which significantly declined to nadir at parturition then rose around to prepartum levels at 30 days postpartum. The NEFA concentration increased from pregnancy to calving and later decreased to achieve prepartum
levels during lactation. The levels of plasma TPP, albumin, globulin and P were highest in pregnancy which declined to nadir at parturition and remained almost unchanged during lactation. Creatinine and Ca concentrations remained unchanged from pregnancy to parturition and then significantly reduced during lactation while urea was significantly lower during pregnancy and rose in lactation. The overall correlation of LEP with biochemical profile revealed positive correlation with TG (r = 0.8), cholesterol (r = 0.69), HDL (r = 0.67), LDL (r = 0.52), globulin (r = 0.56) and P (r = 0.59) while negative correlation with NEFA (r = -0.90) and AG ratio. In addition leptin showed negative correlation with creatinine during pregnancy and lactation. In conclusion, the variations in leptin hormone and other biochemical profiles from pregnancy to lactation, and association of leptin hormone with biochemical profile suggesting its significant physiological role in energy metabolism, body mass and immunity of dairy cows during this crucial period.
References
Al-Mujalli AAM (2008). Studies on some serum constituents of dairy cows in Saudi Arabia. Scientific Journal of King Faisal University (Basic and Applied Sciences) 9:1429.
Aquino-Neto HM (2012). Perfil hidroeletrolítico,ácido-base, metabólico e mineral de vacas leiteiras no pós-parto imediato e avaliação dafluidoterapia oral. 121f. Tese (Doutoradoem Ciência Animal)-Escola de Veterinária,Universidade Federal de Minas Gerais, Bel Horizonte. MG.
Ashmawy NA (2015). Blood metabolic profile and certain hormones concentrations in egyptian buffalo during different physiological state. Asian Journal of Animal and Veterinary Advances 10(6):271-280.
Ate IU, Rekwot PI, Nok AJ and Tekdek LB (2009). Serum electrolyte values of cows during third trimester of pregnancy and early lactation in settled cattle herds in Zaria, Northern Nigeria. African Journal of Biomedical Research 12(2):125-130.
Bell AW (1995). Regulation of organic nutrient metabolism during transition from late pregnancy to early lactation. Journal of Animal Science 73:2804-2819.
Block SS, Butler WR, Ehrhardt RA, Bell AW, Amburgh MEV and Boisclair YR (2001). Decreased concentration of plasma leptin in periparturient dairy cows is caused by negative energy balance. Journal of Endocrinology 171:339-348.
Brzezinska M and Krawczyk M (2009). Changes of the mineral profile of serum of goats in various physiological states. Journal of Elementology 14:649-656.
Chalmeh A, Pourjafar M, Nazifi S, Momenifar F and Mohamadi M (2015a). Study on serum glucose, insulin, NEFA, BHBA and lipid profile in different productive status of high producing Holstein dairy cows. Indian Journal of Veterinary Medicine 9(3):171-178.
Chalmeh A, Pourjafar M, Nazifi S, Momenifar F and Mohamadi M (2015b). Relationships among circulating metabolic biomarkers in healthy high-producing Holstein dairy cows in different physiological states. Journal of Veterinary Medicine 13(1):38-44.
Chilliard Y, Bonnet M, Delavaud C, Faulconnier Y, Leroux C, Djiane J and Bocquie F (2001). Leptin in ruminants. Gene expression in adipose tissue and mammary gland, and regulation of plasma concentration. Domestic Animal Endocrinology 21:271-295.
Dann HM, Litherland NB, Underwood JP, Bionaz M, D’Angelo A, McFadden JW and Drackley JK (2006). Diets during far-off and close-up periods affect periparturient metabolism and lactation in multiparous cows. Journal Dairy Science 89:3563-3577.
De Koster JD and Opsomer G (2013). Insulin resistance in dairy cows. Veterinary Clinics of North America, Food and Animal Practices 29:299-322.
Douglas GN, Overton TR, Bateman HG, Dann HM and Dracley JK (2006). Prepartal plane of nutrition, regardless of dietary energy source, affects periparturient metabolism and dry matter intake in Holstein cows. Journal Dairy Science 89:2141-2157.
Eman MAN, Ghada AEM and Hanan KE (2014) Effect of lactation stages on some blood serum biochemical parameters and milk composition in dairy cows. Assiut Veterinary Medical Journal 60(142):83-88.
Emery RS, Liesman JS and Herdt TH (1992). Metabolism of long chain fatty acids by ruminant liver. Journal of Nutrition 122:832-837.
Eryavuz A, Avci G, Çelik HA and Kucukkurt I (2008). Plasma leptin, insulin, glucose, and urea concentrations throughout lactation in dairy cows. Bulletin of Veterinary Institute Pulawy 52:381-385.
Ferrell CL (1991). Maternal and fetal influences on uterine and conceptus development in the cow: II. Blood Flow and nutrient flux. Journal of Animal Science 69:1954-1965.
García MC, Casanueva FF, Diéguez C and Señarís R (2000). Gestational profile of leptin messenger ribonucleic acid (mRNA) content in the placenta and adipose tissue in the rat, and regulation of the mRNA levels of the leptin receptor subtypes in the hypothalamus during pregnancy and lactation. Biology of Reproduction 62:698-703.
Garverick HA, Harris MN, Vogel-Bluel R, Sampson JD, Bader J, Lamberson WR, Spain JN, Lucy MC and Youngquist RS (2013). Concentrations of nonesterified fatty acids and glucose in blood of periparturient dairy cows are indicative of pregnancy success at first insemination. Journal Dairy Science 96:181-188.
Gavrilova O, Barr V, Marcus-Samuels B and Reitman M (1997). Hyper leptinemia of pregnancy associated with the appearance of a circulating form of the leptin receptor. Journal of Biological Chemistry 272:30546-30551.
Goff JP and Horst RL (1997). Physiological changes at parturition and their relationship to metabolic disorders. Journal Dairy Science 80:1260-1268.
Jaakson H, Ling K, Kaldmäe H, Samarütel J, Kaart T and Kärt O (2007). Influence of pre-partum feeding on periparturient metabolic status in Estonian Holstein cows. Veterinarija Ir Zootechnika 40:62-66.
Jarosz A (2013). Identifi cation of proteins with variable expression in plasma proteome of heifers before insemination and during pregnancy [pol.]. PhD Dissertation, Szczecin, Poland.
Kaneko JJ, Harvey JW and Bruss ML (2008). Clinical biochemistry of domestic animal. 6th Edn, Oxford: Elsevier. p 918.
Karapehlivan M, Atakisi A, Atakisi O, Yuc-ayurt R and Pancarci SM (2007). Blood biochemical parameters during the lactation and dry period in Tuj ewes. Small Ruminant Research 73:267-271.
Konigsson K, Savoini G, Govoni N, Invernizzi G, Prandi A, Kindahl H and Veronesi MC (2008). Energy balance, leptin, NEFA and IGF-1 plasma concentrations and resumption of postpartum ovarian activity in Swedish Red and White breed cows. Acta Veterinaria Scandinavica 50:3-9.
Liesegang A (2008). Influence of anionic salts on bone metabolism in periparturient dairy goats and sheep. Journal of Dairy Science 91:2449-2460.
Meikle A, Kulcsar M, Chilliard Y, Febel H, Delavaud C, Cavestany D and Chilibroste P (2004). Effects of parity and body condition at parturition on endocrine and reproductive parameters of the cows. Reproduction 127:727-737.
Mohri M, Sharifi K and Eidi S (2007). Hematology and serum biochemistry of Holstein dairy calves: age related changes and comparison with blood composition in adults. Research in Veterinary Science 83:30-39.
Moreira TF, Filho EJF, Meneses RM, Mendonça FLM, Lima JAM and Carvalho AU (2015). Energetic status of crossbreed dairy cows during transition period in two different seasons. The Arquivo Brasileiro de Medicina Veterinária e Zootecnia (Brazilian Journal of Veterinary and Animal Science) 67(5):1327-1334.
Nogalski Z, Wroński M, Lewandowska B and Pogorzelska P (2012). Changes in the blood indicators and body condition of high yielding Holstein cows with retained placenta and ketosis. Acta Veterinaria Brno 81:359-364.
Park AF, Shirley JE and Titgemeyer EC (2010). Characterization of plasma metabolites in Holstein dairy cows during periparturient period. Journal Dairy Science 5:253-263.
Pechova A and Pavlata L (2005). The use of metabolic profiles in the control of nutrition of dairy cows. In: Dvořák R (Ed.): Nutrition of Cattle in Terms of Production and Preventive Medicine (in Czech). Noviko, Brno. pp 102-111.
Piccione G, Messina V, Marafioti S, Casella S, Giannetto C and Fazio F (2012). Changes of some haematochemical parameters in dairy cows during late gestation, post-partum, lactation and dry periods. Veterinary Medicine and Zootechnics 58:59-64.
Pullen DL, Palmquist DL and Emery RS (1989). Effect on days of lactation and methionine hydroxyanalog on incorporation of plasma fatty acids into plasma triglycerides. Journal Dairy Science 72:49-58.
Reynolds CK, Aikman PC, Lupoli B (2003). Splanchnic metabolism of dairy cows during the transition from late gestation through early lactation. Journal Dairy Science 86:1201-1217.
Rossato W, González FHD, Dias MM, Riccó D, Valle SF, Rosa VLL, Conceição T, Duarte F and Wald V (2001). Number of lactations affects metabolic profile of dairy cows (O número de lactações afeta o perfil metabólico de vacas leiteiras). Archives of Veterinary Science 6(2):83-88.
Roubies N, Panouis N, Fytianou A, Katsoulos PD, Giadinis N and Karatzias H (2006). Effects of age and reproductive stage on certain serum biochemical parameters of Chios sheep under greek rearing conditions. Journal Veterinary Medicine A 53:277-281.
Shipe WF, Senyk GF and Fountain KB (1980). Modified copper soap solvent extraction method for measuring free fatty acids in milk. Journal Dairy Science 3:193-198.
Skrzypczak W, Kurpińska A, Stański L and Agnieszka Jarosz A (2014). Sodium, potassium and chloride homeostasis in cows during pregnancy and first months of lactation. Acta Biologica Cracoviensia Series Zoologia 55/56: 58-64.
Vaidya MM, Singh VR, Beena M and Upadhyay RC (2015). Plasma profile of hormones and energy metabolites during peri-parturient period in low and high producing Karan Fries (Holstein Friesian × Tharparkar) cows during different seasons. Indian Journal Animal Science 85(7):736-743.
Vargova M and Kováč G (2016). Periparturient period in terms of body condition score and selected parameters of hormonal profile. Folia Veterinaria 60(1):63-69.
Vargová M, Petrovič V, Konvičná J, Kadaši M, Zaleha P and Kováč G (2015). Hormonal profile and body condition scoring in dairy cows during pre partum and post partum periods. Acta Veterinaria Brno 84:141-151.
Yousuf M, Alam MR, Shaikat AH, Faruk MSA, Saifuddin AKM, Ahasan ASML, Islam K and Islam SKMA (2016). Nutritional status of high yielding crossbred cow around parturition. Journal of Advanced Veterinary and Animal Research 3(1):68-74.