Title: Pharmacokinetics of lincomycin following intravenous administration in healthy goats

Authors: Meemansha Sharma, Bhaskar Vemu and VK Dumka

Source: Ruminant Science (2017)-6(2):279-282.

Cite this reference as: Sharma Meemansha, Vemu Bhaskar and Dumka VK (2017). Pharmacokinetics of lincomycin following intravenous administration in healthy goats. Ruminant Science 6(2):279-282.

Abstract

To investigate the pharmacokinetics of Lincomycin after intravenous administration in goats and determine dosage regimen against susceptible micro-organisms. Six healthy female goats were treated with single IV administration of lincomycin @ 10 mg/kg body weight. Blood samples (3-5 ml) were drawn by venepuncture from jugular vein at 0, 1, 2.5, 5, 10, 15, 30 min and 1, 2, 4, 8, 12 and 24 h and plasma were separated from them. The drug was estimated by HPLC by reverse – phase chromatography. The disposition of lincomycin followed the two-compartment open model. The values of AUC (36.7±3.60 µg.ml-1.h and Vdarea (1.33±0.10 L.kg-1), indicated good antibacterial activity and distribution in various body fluids. The elimination half life and MRT values were short (3.27±0.13 and 3.93±0.25 h, respectively). Based on results, lincomycin is suggested to be repeated intravenously in goats at 12 h interval to maintain T>MIC above 50% for bacteria with MIC value up to 0.6 µg.ml-1.

References

Albarellos GA, Montoya L, Denamiel GAA, Velo MC, and Landoni MF (2012). Pharmacokinetics and bone tissue concentrations of lincomycin following intravenous and intramuscular administrations to cats. Journal of Veterinary Pharmacology and Therapeutics 35(6):534-540.

Barragry TB and Powers TE (1994). Aminoglycosides, macrolides, and lincosamides. Veterinary Drug Therapy 241-263.

Bhoi DB, Sutaria TV, Suthar DN and Dadawala AI (2013). Antibiotic sensitivity pattern of repeat breeder cow cervico-vaginal mucous. Ruminant Science 2(1):71-72.

Burrows GE, Barto PB and Weeks BR (1986). Chloramphenicol, lincomycin and oxytetracycline disposition in calves with experimental pneumonic pasteurellosis. Journal of Veterinary Pharmacology and Therapeutics 9(2):213-222.

Burrows GE, Barto PB, Martin B and Tripp ML (1983). Comparative pharmacokinetics of antibiotics in newborn calves: chloramphenicol, lincomycin, and tylosin. American Journal of Veterinary Research 44(6):1053-1057.

Collignon P, Courvalin P and Aidara-Kane A (2008). Clinical importance of antimicrobial drugs in human health. Guide to Antimicrobial Use in Animals. pp 44-58.

 El Sooud K A, Goudah A and El Aty AM (2004). Lack of pharmacokinetic interaction between lincomycin and aspirin in healthy goats. Journal of Veterinary Pharmacology and Therapeutics 27(5):389-392.

Gibaldi M and Perrier D (1982). Pharmacokinetics. In: Multicompartment Models. Eds: Marcel and Dekker. 2nd Edn, New York. pp 45-112.

Giguere S (2013). Lincosamides, pleuromutilins and streptogramins. In: Antimicrobial Therapy in Veterinary Medicine. Eds: S Giguere, JF Prescott and PM Dowling. 5th Edn, John Wiley, Ames, USA. pp 199-210.

Giguere S (2006). Lincosamides, pleuromutilins, and Streptogramins. In: Antimicrobial Therapy in Veterinary Medicine. Eds: S Giguere. 4th Edn, John Wiley, Ames, USA.

Gouri SS, Venkatachalam D and Dumka VK (2014). Pharmacokinetics of lincomycin following single intravenous administration in buffalo calves. Tropical Animal Health and Production 46(6):1099-1102.

Huimin L, Ji-An LI and Jin-Gang NIU (2012). Application of flow feeding technology to lincomycin fermentation. Chinese Journal of Pharmaceuticals 43(9):739-742.

Nielsen P and Gyrd-Hansen N (1998). Bioavailability of spiramycin and lincomycin after oral administration to fed and fasted pigs. Journal of Veterinary Pharmacology and Therapeutics 21(4):251-256.

Papich MG and Riviere JE (2009). Chloramphenicol and derivatives, macrolides, lincosamides, and miscellaneous antimicrobials. In: Veterinary Pharmacology and Therapeutics. Eds: JE Riviere and MG Papich. 9th Edn, Blackwell. pp 963-965.

Petinaki E, Guerin-Faublee V, Pichereau V, Villers C, Achard A, Malbruny B and Leclercq R (2008). Lincomycin resistance gene lnu (D) in Streptococcus uberis. Antimicrobial Agents and Chemotherapy 52(2):626-630.

Sreeshitha SG (2013). Influence of subchronic oral exposure of quinalphos on the pharmacokinetics of lincomycin in buffalo calves. MVSc Thesis submitted to GADVASU, Ludhiana, punjab.

Toutain PL and Lees P (2004). Integration and modelling of pharmacokinetic and pharmacodynamic data to optimize dosage regimens in veterinary medicine. Journal of Veterinary Pharmacology and Therapeutics 27:467-477.

Turnidge JD (1998). The pharmacodynamics of beta-lactams. Clinical Infectious Diseases 27:10-22.

Weber DJ, Barbiers AR and Lallinger AJ (1981). Pharmacokinetics of lincomycin in bovine following intravenous and intramammary doses of lincocin. Upjohn Tehnical Report.