1-Title: Ultrastructural features of the parathyroid glands of the camel (Camelus dromedaries)

Authors: MA Alzayer, AM Ali and SY Al-Ramadan

Source: Ruminant Science (2013)-2(1):1-6.

How to cite this manuscript: Alzayer MA, Ali AM and Al-Ramadan SY (2013). Ultrastructural features of the parathyroid glands of the camel (Camelus dromedaries). Ruminant Science (2013)-2(1):1-6.


The aim of this study was to characterize the parenchymal cells of the parathyroid glands of the camel using electron microscopy. External parathyroid glands from four mature camels were collected and further fixed for ultrastructural analysis. To date, little is known about the cellular components of parathyroid glands in camel. Here, we have show by electron microscopy that parenchyma of camel parathyroid is formed of four types of cells: Active chief cell, inactive chief cell, oxyphil cell and water-clear cell. The most striking result declared in this study is that water-clear cell is stable components of the adult parathyroid glands in the camel. This cell is characterized by intensively vacuolated cytoplasm and linked with some pathologic conditions in human but also detected in other normal animal species. While the general cellular features of active chief cells, inactive chief cells and oxyphil cells are very similar to those described for other species. No multinucleated cell could be detected in all samples examined.


Banks WJ (1993). Parathyroid glands. In: Applied Veterinary Histology. 3rd Edn, Mosby Inc, St Louis, Missouri, p 416.

Barreira C, Cernea CR, Brandão LG, Custódio MR, Caldini E and de Menezes Montenegro FL (2011). Effects of time on ultrastructural integrity of parathyroid tissue before cryopreservation. World Journal of Surgery 35:2440-2444.

Chen H,Emura S and Shoumura S (2006).Ultrastrature of the water-clear cell in the parathyroid gland of SAMP6 mice. Tissue and Cell 38:187-192.

Chen H, Senda T, Emura S and Kubo K (2013). An update on the structure of the parathyroid gland. Open Anatomy Journal 5:1-9.

Collins WT, Capen CC, Döbereiner J and Tokarnia CH (1977). Ultrastructural evaluation of parathyroid glands and thyroid C cells of cattle fed Solanum malacoxylon. American Journal of Pathology 87:603-614.

Emura S, Hayakawa D, Tamada A, Yamahira T, Terasawa K, Isono H  and Shoumura S (1996). Ultrastructural changes in water-clear cells of the golden hamster parathyroid gland after streptozotocin treatment. Okajimas Folia Anatomica Japonica 73:7-13.

Haynes JI (1999). Parathyroids and ultimobranchial bodies in monotremes. Anatomical Record 254:269-280.

Isono H, Shoumura S and Emura S (1990). Ultrastructure of the parathyroid gland. Histology and Histopathology 5:95-112.

Kanter M (1996). The occurrence of multinucleated cells in parathyroid glands of sheep and rats. Yüzüncü YıL Üniversitesi Veteriner Fakultesi Derg 7:54-57.

Kuhel WI, Gonzales D, Hoda SA, Pan L, Chiu A, Giri D and DeLellis RA (2001). Synchronous water-clear cell double parathyroid adenomas a hitherto uncharacterized entity? Archives of Pathology and Laboratory Medicine 125:256-259.

Livolsi VA (2002). Parathyroid Morphology and Pathology. In: Endocrine Pathology. Eds VA Livolsi and SL Asa, Churchill Livingstone, Philadelphia,US pp 1-15.  

Marti R, Wild P, Schraner EM, Mueller M and Moor H (1987). Parathyroid ultrastructure after aldehyde fixation, high-pressure freezing, or microwave irradiation. Journal of Histochemistry and Cytochemistry 35:1415-1424.

Matsushima S, Tsuchiya N, Fujisawa-Imura K, Hoshimoto M, Takasu N, Torii M, Ozaki K, Isao N and Kotani T (2005). Ultrastructural and morphometrical evaluation of the parathyroid gland in iron-lactate-overloaded rats. Toxicologic Pathology 33:533-539.

Metwally MA  and Attia HF (2006). Anatomical and histological studies on the parathyroid gland of the camel (Camelus dromadrius). International Scientific Conference on Camel. Saudi Arabia, pp 1484-1494.

Munger BL and Roth SI (1963). The cytology of the normal parathyroid glands of man and Virginia deer: A light and electron microscopic study with morphologic evidence of secretory activity. Journal of Cell Biology 16:379-400.

Nunez EA, Whalen JP and Krook L (1972). An ultrastructural study of the natural secretory cycle of the parathyroid gland of the bat. American Journal of Anatomy 134:459-479.

Ream LJ and Principato R (1981). Fluoride stimulation of the rat parathyroid gland: An ultrastructural study. American Journal of Anatomy 162:233-241.

Samuelson DA (2007). Parathyroid glands. In: Textbook of Veterinary Medicine, 1st Edn, Elsevier Inc,Philadelphia, US, pp 409-411.

Setoguti T (1977). Electron microscopic studies of the parathyroid gland of senile dogs. American Journal of Anatomy 148:65-83.

Wild P, Kellner SJ and Schraner EM (1987). Parathyroid cell variants may be provoked during immersion fixation. Histochemistry 87:263-271.