10-Title: Pharmacokinetics of moxifloxacin following intramuscular administration in Berari goat a saline tract breed of Vidarbha region
Authors: N Rathod, S Kukade, MK Lonare and SW Hajare
Source: Ruminant Science (2014)-3(1):45-49.
How to cite this manuscript: Rathod N, Kukade S, Lonare MK and Hajare SW (2014). Pharmacokinetics of moxifloxacin following intramuscular administration in Berari goat a saline tract breed of Vidarbha region. Ruminant Science 3(1):45-49.
The present study was conducted on six healthy male Berari goats to study the kinetic disposition of moxifloxacin following its single intramuscular administration @ 5 mg/kg body weight. The plasma drug concentration of moxifloxacin was assayed by microbiological assay with bacterial strain of E. coli (ATCC-25922TM). The sensitivity of moxifloxacin microbiological assay was 0.312 µg/ml. The mean peak plasma concentration (Cmax) of Moxifloxacin following its administration as single dose in male goats was 18.77±0.30 mg.ml-1 with time required to attain the peak concentration (Tmax) was 3.33±0.42 h. Following intramuscular administration of moxifloxacin in male goats, the mean values of elimination rate (β), elimination half-life (t½β), plasma drug concentration-time curve from zero to infinity (AUC0-”), area under the first order moment curve from zero to infinity (AUMC0-”),mean residence time (MRT), apparent volume of distribution (Vd(area)) and total body clearance (CLB) were 0.34±0.03 h-1, 2.07±0.19 h, 89.67±1.42 mg.h.ml-1, 331.11±7.08 mg.h2.ml-1, 3.69±0.05 h, 5.96±0.72 L.kg-1 and 1.94±0.04 L.h-1.kg-1, respectively. On the basis of present investigation it was concluded that moxifloxacin have very good Cmax, AUC to MIC ratio so this dose can be intramuscularly administered in Berari goats in bacterial infections.
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