6-Title: Periparturient hormonal profile and therapeutic management of cervicovaginal prolapse in Murrah buffaloes

Authors: BL Sharma, VK Bhatt, MK Shukla, Swadesh Thapak, KK Gupta, Satendra Sharma and Rahul Parasar

Source: Ruminant Science (2014)-3(1):29-32.

How to cite this manuscript: Sharma BL, Bhatt VK, Shukla MK, Thapak Swadesh, Gupta KK, Sharma Satendra and Parasar Rahul (2014). Periparturient hormonal profile and therapeutic management of cervicovaginal prolapse in Murrah buffaloes. Ruminant Science (2014)-3(1):29-32.


The present clinical study was conducted on 24 buffaloes suffering of cervicovaginal prolapsed during the last month of gestation. The cases were classified as 1st, 2nd and 3rd degree on the basis of severity and treated with different therapeutic regimes as per severity. The Plasma progesterone and estrogen concentration on the day of prolapse, day of parturition and day 10 post partum were recorded. The plasma progesterone concentration on the respective days was 1.91±0.07, 1.11±0.11 and 1.12±0.05 ng/ml whereas the respective values for plasma estrogen concentration were 176.57±1.50, 185.68±0.99 and 96.55±8.72 pg/ml. The results of the present study indicate that hormonal imbalance particularly low progesterone and high estrogen during later part of gestation period may be predisposing factor for cervico-vaginal prolapsed.


Akhtar MS, Lodhi LA, Ahmad I, Qureshi ZI and Muhammad G (2012). Serum ovarian steroid hormones and some minerals concentration in pregnant Nili-Ravi buffaloes with or without pre-partum vaginal prolapse. Pakistan Veterinary Journal 253(3):265-268.

Bakshi SA, Panchbhai VS, Pangaonkar GR and Anantwar LG (1990). A note on prolapse of genitalia in cows and buffaloes. Livestock Advisor 15(2):32-34.

Benediktsson R (1995). The role of β- hydroxysteroid dehydrogenase in controlling fetal glucucorticoid exposure. PhD Thesis submitted to University of Edenberg, UK.

Chavance J (1944). Hernia and prolapse of vagina in case of rickets. Veterinary Bulletin 16:89-93.

Dugwekar YG, Sarvaiya NP and Patel MD (2008). Serum progesterone and estradiol levels in Jafarabadi buffaloes. Indian Journal of Animal Reproduction 29(2):177-180.

El-Belely MS, Zaki K and Grunert E (1988). Plasma profiles of progesterone and total oestrogens in buffaloes (Bubalus bubalis) around parturition. Journal of Agriculture Science 111:519-524.

El-Wishy AB (2007). The postpartum buffalo: Endocrinological changes and uterine involution. Animal Reproduction Science 97:201-215.

Fairclough RJ, Hunter JT and Welch RA (1978). Peripheral plasma progesterone and utero ovarian progesterone concentration in the cow around parturition. Indian Journal of Animal Reproduction 9(2):501-514.

Gasperlin B, Zadnik T, Jazbec I and Zust J (2002). Effects of dietary cation-anion differences on serum calcium, phosphorus and magnesium concentrations in periparturient dairy cows. Veterinary Research 39:215-225.

Jana D and Mousumi J (2005). Post-partum cervico-vaginal prolapse with partial uterine prolapse in a pluriparous indigenous she buffalo. Intas Polivet 6(1):30-31.

Khan MZ (1981). Studies on the ante-partum prolapse of vagina in buffaloes. MVSc Thesis submitted to HAU, Hisar.

Khan MZ, Verma SK, Khar SK, Gupta RC and Sharma AK (1984). Studies on ante-partum prolapse of vagina in buffaloes III. Plasma calcium, phosphorus and magnesium concentration. Haryana Agriculture University Journal of Research 14(3):282-285.

Lohan IS, Kaker ML and Razdan MN (1987). Prepartum and immediate post-partum blood plasma progesterone, estradiol LH and FSH profile of Murrah buffaloes. Indian Journal of Animal Reproduction 8(2):121-126.

Mishra UK, Agrawal RG and Pandit RK (1998). Incidence of prolapse of genitalia in Murrah buffaloes in relation to season, pregnancy, parity and management. Indian Veterinary Journal 75(3): 254-255.

Mulligan F, Grady LO, Rice D and Doherty M (2006). Production diseases of the transition cow: Milk fever and subclinical hypocalcaemia. Irish Veterinary Journal 59(12):697-702.

Murugavel K (2002). An unusual case of vaginal prolapse in a heifer. Indian Veterinary Medicine Journal 26(3):81-82.

Nakamura Y, Miki Y and Sasano H (2003). Steroid sulphatase and estrogen sulphotransferase in the atherosclerotic human aorta. Animal Journal of Pathology 163:1329-1339.

Nanda AS and Sharma RD (1982). Incidence and aetiology of prepartum prolapse of vagina in buffaloes. Indian Journal of Dairy Science 35(2):168-171.

Pandey AK, Shukla SP and Nema SP (2007). Certain haemato-biochemical alterations during post-partum uterine prolapse in buffaloes (Bubalus Bubalis). Buffalo Bulletin 26(1):20-22.

Roberts SJ (1986). Veterinary Obstetrics and Genital Diseases. 3rd Edn, Edward Brothers Michigan, USA, pp 233-240.

Sah SK and Nakao T (2003). Some characteristic of vaginal prolapse in Nepali buffaloes. Journal of Veterinary Medicine 65:1213-1215.

Samad HA, Ali CS, Reahman NU, Ahmad A and Ahmad N (1987). Clinical incidence of reproductive disorders in buffalo. Pakistan Veterinary Journal 7(1):16-19.

Sarvaiya NP, Mehta VM and Patel AV (1993). Blood serum estradiol -17β and progesterone around parturition in Surti buffaloes. Indian Journal of Animal science 63(3):294-295.

Seitaridis K and Papadopoulos E (1978). Contributions to the aetiology of vaginal prolapse in pregnant cows. Veterinary Bulletin 48:50-58.

Sharma BL, Bhatt VK, Jain SK, Shukla SN, Shukla MK, and Quadri MA.(2014). Hormonal Profile in peri-partuirient buffaloes with cervico-vaginal prolapse. Indian Veterinary journal 91(8):96-97.

Verma SK, Sharma AK, Gupta RC and Tyagi RPS (1979). Vaginal prolapse in buffaloes. Philipines Journal of Veterinary Medicine 18(2):131-140.