32-Title: Studies on the efficacy of fresh Aloe vera pulp on wound healing in calves
Authors: Abhishek Verma, Dharmendra Kumar, Anuradha Nema, TJ Sheikh, Mansi Shukla, Rajesh Ranjan and Payal Jain
Source: Ruminant Science (2020)-9(1):155-158.
How to cite this manuscript: Verma Abhishek, Kumar Dharmendra, Nema Anuradha, Sheikh TJ, Shukla Mansi, Ranjan Rajesh and Jain Payal (2020). Studies on the efficacy of fresh Aloe vera pulp on wound healing in calves. Ruminant Science 9(1):155-158.
Present study was conducted on 12 calves having fresh wound of size 16-25 cm2 anywhere on the body except joints to evaluate the wound healing using fresh Aloe vera leaf paste. These were randomly divided into two groups for further treatment. Wounds of group I were treated with normal saline solution whereas, that of group II were applied with Aloe vera leaf paste. Temperature pulse and respiration were recorded from 0 to 5th post-treatment day of each animal in both the groups. All the values fluctuated within the normal physiological range. Exudates and pain were of the lower degree in cases treated with Aloe vera as compared to normal saline solution treated group. Observation of wound on 20th day showed intense red colouration in wounds of normal saline solution treated group suggesting proliferative phase but the colour of the wound treated with Aloe vera were whitish brown suggesting almost healed wound. There was a significant difference between the treatment and control group in wound contraction rate on 5th, 10th, 15th, 20th and 25th post treatment day. An accelerated wound contraction was seen in Aloe vera treated group during all stage of wound healing wounds, which might be due to its property of initiating early angiogenesis, fibroblatosis and stimulating proliferation of keratinocytes.
Chah K, Eze CA, Emuelosi CE and Esimone CO (2006). Antibacterial and wound healing properties of methanolic extracts of some Nigerian medicinal plants. Journal of Ethnopharmacol 104:164-167.
Das K (2013). Wound healing potential of aqueous crude extract of Stevia rebaudiana in mice. Revista Brasileira de Faracognosia 23(2):351-357.
Davis RH, Donato JJ, Hartman GM and Haas RC (1994). Antiinflammatory and wound healing activity of a growth substance in Aloe vera. Journal of the American Pediatric Medical Association 84(2):77- 81.
Gupta VK and Malhotra S (2012). Pharmacological attribute of Aloe vera: revalidation through experimental and clinical studies. Ayu 33:193-196.
Habeeb F, Shakir E, Bradbury F, Cameron P, Taravati MR, Drummond AJ, Gray AI and Ferro VA (2007). Screening methods used to determine the anti-microbial properties of Aloe vera inner gel. Methods 42(4):315-320.
Kayode OA (2017). Effects of Aloe vera gel application on epidermal wound healing in the domestic rabbit. International Journal of Research in Medical Sciences 5(1):101-105.
Kumar D, Sharma SP, Lugun AK, Shekhar S and Kumar N (2006). Efficacy of Tagetes erectas as a wound healing agent in buffalo calves. Indian Journal of Veterinary Surgery 27(1):53-54.
Moriyama M, Kubo H, Nakajima Y, Goto A, Akaki J, Yoshida I, Nakamura Y, Hayakawa T, Moriyama H (2016). Mechanism of Aloe vera gel on wound healing in human epidermis. Journal of Dermatological Science 84(1):3-10.
Nandanwar R, Gurjar H, Sahu VK and Saraf H (2010). Studies on wound healing activity of gel formulation containing cow ghee and Aloe vera. International Journal of Pharmaceutical Sciences and Research 1(3):50-54.
Newman DJ, Cragg GM and Snader KM (2016). Natural products as sources of new drugs over the period. Journal of Natural Product 66:1022-1037 .
Nguyen DT, Orgill DP and Murphy GF (2009). The pathophysiologic basis for wound healing and cutaneous regeneration. In: Biomaterials for Treating Skin Loss. pp 25-57.
Oryan A, Naeini AT, Nikahval B and Gorjian E (2010). Effect of aqueous extract of Aloe vera on experimental cutaneous wound healing in rat. Journal Veterinarski Arhiv 80(4):509-522.
Pawar RS and Toppo FA (2012) Plants that heal wounds-A review. Hebra Polonia 58(1):47-65.
Sharma N (2018). Evaluation of herbal medicaments for wound healings in dogs. MVSc and AH thesis submitted to Nanaji Deshmukh Veterinary Science University, Jabalpur.
Singh H and Singh K (2020). Wound healing and tissue repair. In: Ruminant Surgery. Eds: J Singh. S Singh and RPS Tyagi. 2st Edn, CBS Publishers and Distributors New Delhi. pp 105-120.
Singh MP, Bharghava S, Bhaduaria RS and Sharma CS (2010). Wound healing potential of alcoholic extract of Mimosa pudica Linn leaves. Pharmacology Online 2:32-38.
Takjare N, Hosseini M, Hasanzadeh G and Mortazavi H (2009). Influence of Aloe vera gel on dermal wound healing process in rats. Toxicology Mechanism and Methods 19:73-77.
Vazquez B, Avila G, Segural D and Escalante B (1996). Antiinflammatory activity of extracts from Aloe vera gel. Journal of Ethnopharmacology 55:69 75.