16-Title: Gamma-glutamyl transferase an oxidative stress marker in nondescript goats of arid tract

16-Title: Gamma-glutamyl transferase an oxidative stress marker in nondescript goats of arid tract

Authors: Archita Singh and Nalini Kataria

Source: Ruminant Science (2023)-12(1):91-94.

How to cite this manuscript: Singh Archita and Kataria Nalini (2023). Gamma-glutamyl transferase an oxidative stress marker in nondescript goats of arid tract. Ruminant Science 12(1):91-94.


The present exploration was planned to determine the association of GGT as an oxidative stress marker in non-descript goats of the arid tract. To execute the objectives, blood samples were collected from non-descript male (N=60) and female (N=60) goats (Post pubertal) of 5-11 months of age from private slaughter houses of arid tract. The samples were collected during a moderate environmental temperature period (October to November) and an extreme hot environmental temperature period (May to June), from age groups 5-7 months (N=20); 7-9months (N=20); and 9-11 months (N=20) of each sex. The magnitude of GGT concentration in plasma assessed during extreme hot environmental temperature period were compared to those analyzed during moderate environmental temperature period. The assessment reflected the effect of hot ambient temperature on plasma GGT, in the goats of all age groups and sexes. Its mean value obtained during a moderate environmental temperature period was considered as a control value and was found to increase, under bang of heat stress irrespective of age and sex. Significant (p<0.05) changes in mean values were observed due to sex and age in both moderate and extreme hot ETPs. In both the ETPs, mean values were found to be significantly (p<0.05) higher in male goats as compared to female goats. Mean values assessed during both the ETPs were found to be highest in 9-11 months age group and lowest in 5-7 month age group. It can be reiterated that extent of development of oxidative stress was higher during extreme hot environmental temperature period. Higher GGT value in plasma attempted to illustrate the apparition of oxidative stress in otherwise healthy goats. The present investigation was done to know precautionary measures to be taken for the survival of goats in arid tract without compromising production


Barrios R, Shi ZZ, Kala SV, Wiseman AL, Welty SE, Kala G, Bahler AA, Ou CN and Lieberman MW (2001). Oxygen-induced pulmonary injury in gamma-glutamyl transpeptidase-deficient mice. Lung 179(5):319-30.

Chaturvedi M, Kataria N and Kataria AK (2012). Extreme ambiences associated variations in erythrocytic glutathione reductase levels in Marwari goat. Ruminant Science 1(2):137-140.

Gonenci R, Durgut R, Erdogan S, Bal R and Celik S (2003). Subclinical fatty liver syndrome in Damascus goats. Indian Veterinary Journal 80(8):739-742

Hanigan MH and Ricketts WA (1993). Extracellular glutathione is a source of cysteine for cells that express gamma-glutamyl transpeptidase. Biochemistry 32(24):6302-6.

Ikeda Y, Fujii J, Taniguchi N and Meister A (1995). Expression of an active glycosylated human gamma-glutamyl transpeptidase mutant that lacks a membrane anchor domain. Proceedings of National Academy of Science 92(1):126-30.

Jean JC, Liu Y, Yue Liu, Lou Ann Brown, Robert E Marc, Elizabeth Klings and Martin Joyce-Brady (2002). Glutamyl transferase deficiency results in lung oxidant stress in normoxia. American Journal of Physiology-Lung Cellular and Molecular Physiology 283:766-76.

Jezek J, Klopcic M and Klinkon M (2006). Influence of age on biochemical parameters in calves. Bulletin of the Veterinary Institute in Pulawy 50(2):404-408

Joshi A (2012). Ambience associated variation in the serum biomarkers of oxidative stress in buffalo of arid track. MVSc thises submitted to RAJUVAS, Bikaner.

Kataria AK, Kataria N, Pachaury R and Gahlot AK (2013). A cross-sectional study on magnitude of diseases of domestic animals in Rajasthan. Veterinary Practitioner 14(1):159-63.

Kataria N and Kataria AK (2012). Use of serum gamma glutamyl transferase as a biomarker of stress and metabolic dysfunctions in Rathi cattle of arid tract in India. Journal of Stress Physiology and Biochemistry 8(3):23-9.

Kataria Nalini, Joshi Ashish, Saini Bhagat Singh, Arora Sunil, Singla Banita, Mohammed Nazeer, Asopa Shesh and Kataria AK (2014). Relationship of aldosterone with electrolytes and oxidative stress during hot ambience in Marwari goats from arid tracts. Ruminant Science 3(2):211-215.

Kataria N, Kataria AK, Chaturvedi M and Sharma A (2011). Changes in serum enzymes levels associated with liver functions in stressed Marwari goat. Journal of Stress Physiology and Biochemistry 7(1):13-9.

Komal, Rnajan Ayush, Gattani Anil, t KumarAjee, Sanjana, Kumar Deepak, Anjay and Sinha Manoj Kumar (2022). Assessment of oxidative stress biomarkers in moneiziosis in goats. Ruminant Science 11(2):455-458.

Kugelman A, Choy HA, Liu R, Shi MM, Gozal E and Forman HJ (1994). Gamma-Glutamyl transpeptidase is increased by oxidative stress in rat alveolar L2 epithelial cells. American Journal of Respiratory Cell and Molecular Biology 11(5):586-92.

Lieberman MW, Wiseman AL, Shi ZZ, Carter BZ, Barrios R, Ou CN, Chévez-Barrios P, Wang Y, Habib GM, Goodman JC and Huang SL (1996). Growth retardation and cysteine deficiency in gamma-glutamyl transpeptidase-deficient mice. Proceedings of the National Academy of Sciences 93(15):7923-6.

Liu RM, Hu H, Robison TW and Forman HJ (1996). Increased gamma-glutamylcysteine synthetase and gamma-glutamyl transpeptidase activities enhance resistance of rat lung epithelial L2 cells to quinone toxicity. American Journal of Respiratory Cell and Molecular Biology 14(2):192-7.

Matsha TE, Macharia M, Yako YY, Erasmus RT, Hassan MS and Kengne AP (2014). Gamma-glutamyltransferase, insulin resistance and cardiometabolic risk profile in a middle-aged African population. European Journal of Preventive Cardiology 21(12):1541-8.

Meister A (1973). On the enzymology of amino acid transport: Transport in kidney and probably other tissues is mediated by a cycle of enzymic reactions involving glutathione. Science 180(4081):33-9.

Targher G, Seidell J, Tonoli M, Muggeo M, De Sandre Gi and CigolinI M (1996). The white blood cell count: its relationship to plasma insulin and other cardiovascular risk factors in healthy male individuals. Journal of Internal Medicine 239(5):435-41.

Thori MK (2015). The physiological stress responses and oxidative stress biomarkers in Rathi calves during hot ambience. MVSc thesis submitted to RAJUVAS, Bikaner.

Wolf PL, Williams D and Von der Muehll E (1973). Practical clinical enzymology and biochemical profiling: Techniques and interpretations. Clinical Chemistry 20(4):517.