19-Title: Association between polymorphism of STAT5A gene and milk production traits and quality traits in crossbred cattle of Kerala
Authors: Haritha B Pillai, Naicy Thomas, Elizabeth Kurian, TV Aravindakshan, Lali F Anand, V Babitha and Sreeja R Nair
Source: Ruminant Science (2023)-12(2):285-290.

Abstract

How to cite this manuscript: Pillai Haritha B, Thomas Naicy, Kurian Elizabeth, Aravindakshan TV, Anand Lali F, Babitha V and Nair Sreeja R (2023). Association between polymorphism of STAT5A gene and milk production traits and quality traits in crossbred cattle of Kerala. Ruminant Science 12(2):285-290.
Abstract
Signal transducer and activator of transcription 5A (STAT5A) is a transcription factor that plays a crucial role in the development of the mammary gland. It acts as a critical mediator of prolactin signalling and is capable of initiating the transcription of milk protein genes in response to prolactin. The STAT5A gene has a major role in mammary gland development and lactogenesis and is suggested as a candidate gene for dairy cattle production traits. The present study was carried out in Crossbred cattle of Kerala to evaluate the association between polymorphism of STAT5A gene and milk production traits and quality traits (305-day milk yield, peak yield, average daily yield, fat per cent and solids not fat (SNF) per cent). A total of 180 crossbred cows were genotyped using High-resolution melt curve analysis. Allele frequencies of T and C alleles were 0.58 and 0.42 respectively. The frequencies of genotype CC, genotype CT and genotype TT were 0.44, 0.28 and 0.28, respectively. The impact of the genotypes of the c.2049C>T polymorphism in the STAT5A gene on milk production traits in crossbred animals was studied. Peak yield was significantly (pd”0.05) higher in animals with CT genotype compared to CC and TT genotypes. Association analysis of genotypes with other traits were found to be statistically insignificant (p>0.05). The results suggest that STAT5A can be used as a candidate gene for milk production traits.
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