2-Title: Oxidative stress, immunological and systemic inflammatory changes in lumpy skin disease affected cattle

Authors: Sandeep, Dhawal Kant Yadav, Amit Kumar, JP Kachhawa, Sita Ram Gupta, AP Singh and Rajender Yadav

Source: Ruminant Science (2023)-12(1):9-12.

How to cite this manuscript: Sandeep, Yadav Dhawal Kant, Kumar Amit, Kachhawa JP, Gupta Sita Ram, Singh AP and Yadav Rajender (2023). Oxidative stress, immunological and systemic inflammatory changes in lumpy skin disease affected cattle. Ruminant Science 12(1):9-12.

Abstract

The present study was conducted to access the alterations in oxidative stress markers, immunological markers, and inflammatory markers in Lumpy skin disease (LSD)-affected cattle. Thirty-two adult cattle irrespective of sex and breed were selected out of which eight animals were observed and inspected as apparently healthy and considered as the control group and the other 24 animals with apparent clinical signs and confirmed positive by PCR were considered as the infected group. Clinical manifestations were observed and blood as well as sera samples were collected from both groups. Results of oxidative stress markers revealed that significant decrease in TAC and GSH-Px, while a significant increase in MDA and CAT in the serum of LSD-affected animals. Serum immunological markers revealed a significant increase in values of IgG and IgM in diseased animals. The results of inflammatory cytokines revealed that significant increase in IL-4, TNF-alpha, and IFN-gamma in affected animals. This study indicates that LSDV infection provokes oxidative stress and systemic inflammation as well as stimulates the host response to viral infection. This study will help in exploring the pathogenesis of LSD and adopting an anti-oxidant, immunomodulatory, and anti-inflammatory remedial strategy for LSD-affected animals.

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