29-Title: Influence of general anaesthesia on disposition kinetic of ceftiofur in buffaloes with diaphragmatic hernia
Authors: Raut Akash, Simrat PS Saini, Milindmitra Lonare, Arun Anand, Rajdeep Kaur, Deepesh Kumar and Vinod K Dumka
Source: Ruminant Science (2021)-10(1):147-154.
How to cite this manuscript: Akash Raut, Saini Simrat PS, Lonare Milindmitra, Anand Arun, Kaur Rajdeep, Kumar Deepesh and Dumka Vinod K (2021). Influence of general anaesthesia on disposition kinetic of ceftiofur in buffaloes with diaphragmatic hernia. Ruminant Science 10(1):147-154.
The present study was undertaken to generate the pharmacokinetic data of ceftiofur sodium under the influence of general anaesthesia in buffaloes undergoing surgery for diaphragmatic hernia. Ceftiofur sodium was administered to buffaloes at the dose rate of 2.2 mg/kg of body weight by intramuscular route. Plasma concentrations of desfuroylceftiofur acetamide as derivatized ceftiofur metabolite were determined using HPLC system. Quantifiable plasma concentration of ceftiofur was detected up to 24 hours. Pharmacokinetic parameters were calculated using non-compartmental model. The peak plasma concentration (Cmax) of ceftiofur was found to be 15.69±0.69 µg/ml after 1 hour (Tmax), and the elimination half-life value was 8.23± 0.77 hours. The volume of distribution (Vz/F) was 0.39±0.03 L/kg and clearance rate (Cl/F) was 33.18± 0.001 mL.kg-1.h-1. The observed in vitro plasma protein binding of ceftiofur in buffaloes was 40.81±1.97 per cent and the calculated % T>MIC value of 85.22% suggests that the bactericidal concentration of the test drug was maintained up to 24 hours against the organisms having MIC value of 1.0 µg/ml. The pharmacokinetic data and the calculated value of % T>MIC, suggest that ceftiofur sodium @ 2.2 mg/kg body weight, (i.m.) at 24 hours intervals may be sufficient in buffaloes undergoing the surgical operation of diaphragmatic hernia under general anaesthesia.
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