30-Title: Safety assessment of amikacin after repetitive intramuscular administration in goats
Authors: Namrata Upadhyay, Nitesh Kumar, Arpita Shrivastav, Swatantra Singh, Neeraj Shrivastava, Jitendra Kumar and Rajeev Ranjan
Source: Ruminant Science (2021)-10(1):155-159.
How to cite this manuscript: Upadhyay Namrata, Kumar Nitesh, Shrivastav Arpita, Singh Swatantra, Shrivastava Neeraj, Kumar Jitendra and Ranjan Rajeev (2021). Safety assessment of amikacin after repetitive intramuscular administration in goats. Ruminant Science 10(1):155-159.
Abstract
Amikacin is an aminoglycoside antibiotic used to treat infections caused by more resistant strains of Gram-negative bacteria and some Gram-positive bacteria. Clinically low therapeutic index of this antibiotic may lead to adverse changes in haemato-biochemical and urine parameters, especially associated with liver and kidney. Amikacin (10 mg/kg b.wt.) was administered through an intramuscular route repeatedly for 5 days in four healthy non-lactating female goats. Blood samples were collected on days 0, 2nd, 4th and 6th and analyzed by using standard diagnostic kits. There was a significant (p<0.05) increase in plasma creatinine and blood urea nitrogen levels on day 4th, with no significant change in blood haemoglobin, packed cell volume, total erythrocytes count, total leucocytes counts, lymphocytes, monocytes, eosinophils, basophils and neutrophils and the serum albumin, globulin, total protein, bilirubin, cholesterol and triglyceride concentration on the 0, 2nd, 4th and 6th day were observed. Further significant (p<0.05) increase in alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase levels were observed during the course of amikacin administration. Urine analysis did not show any significant change in specific gravity, pH, pus cells and epithelial cells, and other parameters like bile salt, ketone body, albumin, RBCs, cast and crystal were not detected in urine during the entire study period. The results conclude that amikacin did not alter the haemato-biochemical and urine parameters, in female goats after repeatedly intramuscular administration at therapeutic dose.
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