37-Title: Pharmacokinetics of cefquinome after a single intramuscular injection in cows with clinical dystocia
Authors: Kishor Kumar DG, Rajdeep Kaur, Navdeep Singh, Suresh Kumar Sharma and Simrat Pal Singh Saini
Source: Ruminant Science (2022)-11(1):181-185.
How to cite this manuscript: Kumar DG Kishor, Kaur Rajdeep, Singh Navdeep, Sharma Suresh Kumar and Saini Simrat Pal Singh (2022). Pharmacokinetics of cefquinome after a single intramuscular injection in cows with clinical dystocia. Ruminant Science 11(1):181-185.
Abstract
The pharmacokinetics of cefquinome in cows (n=6) with clinical dystocia was studied following single intramuscular (IM) administration (1 mg.kg-1 bodyweight). Blood samples were collected prior to and up to 24 h after drug administration. No adverse effects or changes were observed after the IM injection of cefquinome. Plasma concentrations of cefquinome were determined by high-performance liquid chromatography. The plasma concentration-time curves following IM administration were best described by one-compartment open model. The important pharmacokinetic parameters after IM administration analyzed (Mean±SE) were maximum plasma concentration (Cmax) 3.54±0.10 µg.ml-1, time to achieve Cmax (tmax) 1 h, absorption rate constant (Ka) 5.53±0.36 h-1, absorption half-life (t1/2ka) 0.12±0.008 h, elimination rate constant (ß) 0.61±0.05 h-1, elimination half-life (t1/2ß)1.12±0.009 h, apparent volume of distribution (Vdarea) 0.13±0.004 L.kg-1, area under the concentration–time curve (AUC) 12.33±0.41 µg.ml-1.h and mean residential time (MRT) 2.39±0.004 h. The in vitro plasma protein binding of cefquinome was 12.56±0.56% at plasma concentrations between 1.25-20.00 µg.ml-1. Cefquinome at a dose of 1 mg.kg-1 body weight by IM administration was sufficient to maintain % T>MIC above 50 % for bacteria having MIC900.50 µg.ml-1 only for a period of 8h in cattle with clinical dystocia.
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