5-Title: Study on 5-fluorouracil as adjunct therapy in bovine squamous cell carcinomas
Authors: MJ Desai, PT Sutaria, SH Raval, PB Patel, Dixit Parmar and Gautam Makwana
Source: Ruminant Science (2024)-13(1):27-38.

Abstract

How to cite this manuscript: Desai MJ, Sutaria PT, Raval SH, Patel PB, Parmar Dixit and Makwana Gautam (2024). Study on 5-fluorouracil as adjunct therapy in bovine squamous cell carcinomas. Ruminant Science 13(1):27-38.
Abstract
The present study was conducted on 12 animals with squamous cell carcinoma to evaluate the effect of 5-fluorouracil in preventing reoccurrence after surgical excision. In the treated group, no reoccurrence of SCC was reported except in 1 cow in which regional metastasis to parotid lymph node was reported 135 days after surgery. In surgically excised animals, only 1 cow with vulvar SCC showed reoccurrence after 157 days of surgery. Administration of 5-fluorouracil (5FU) in surgical beds prevented the reoccurrence of most moderately differentiated squamous cell carcinoma despite evidence of tumour cell remnants in the surgical bed. However, regrowth was observed in poorly differentiated tumours having a high mitotic index.
References
Al-Jameel W, Al-Mahmood SS and Al-Saidya AM (2022). Correlation between p53 and Mdm2 expression with histopathological parameters in cattle squamous cell carcinomas. Veterinary World 15(1):10.
Baniadam A, Moezzi N and Mohammadian B (2010). Nasal squamous cell carcinoma in a cow. Turkish Journal of Veterinary and Animal Sciences 34(3):303-305.
Constable PD, Hinchcliff KW, Done SH and Grünberg W (2017). Veterinary Medicine. 11th Edn, Elsevier Health Sciences. pp 956-1112.
Diasio RB and Harris BE (1989). Clinical pharmacology of 5-fluorouracil. Clinical Pharmacokinetics 16:215-237.
Edwards B (2001). Regional anesthesia techniques in cattle. In Practice 23(3):142-149.
Eisenberg DP, Adusumilli PS, Hendershott KJ, Yu Z and Mullerad M (2005). 5-fluorouracil and gemcitabine potentiate the efficacy of oncolytic herpes viral gene therapy in the treatment of pancreatic cancer. Journal of Gastrointestinal Surgery 9(8):1068-1079.
Fortier LA and Mac Harg MA (1994). Topical use of 5-fluorouracil for treatment of squamous cell carcinoma of the external genitalia of horses: 11 cases (1988-1992). Journal of the American Veterinary Medical Association 205(8):1183-1185.
Gharagozlou MJ, Hekmati P and Ashrafihelan J (2007). A clinical and histopathological study of ocular neoplasms in dairy cattle. Veterinary Archives 77(5):409.
Hillman R and Gilbert RO (2008). Reproductive disease. In: Rebhun’s Diseases of Dairy Cattle. 3rd Edn, Missouri, USA: Saunders. pp 395-446.
Khalil A, Zeineldin M, Amin A, Shehata S and El-Khodery S (2020). Prevalence and factors associated with superficial tumors and tumors-like swelling in cattle and buffalo in Egypt. Mansoura Veterinary Medical Journal 21(4):155-160.
Khansur T and Kennedy A (1991). Cisplatin and 5 fluorouracil for advanced locoregional and metastatic squamous cell carcinoma of the skin. Cancer 67(8):2030-2032.
Khodakaram-Tafti A, Motaghypisheh M and Shirian S (2013). Pathological study of naturally occurring vulvar and vaginal squamous cell carcinoma (SCC) in cattle. Comparative Clinical Pathology 22(4):713-716.
Luna LG (1968). Manual of Histologic Staining Methods of the Armed Forces Institute of Pathology. 3rd Edn, Blackiston Division, Mc Graw Hill, New York. pp 38-39.
Magotra Ankit, Pander BL, Malik BS and Khurana R (2016). Autohaemotherapy as a treatment method for bovine papillomatosis in hardhenu (Bos taurus x Bos indicus) cattle. Ruminant Science 5(1):131-132.
Mair TS and Couto CG (2006). The use of cytotoxic drugs in equine practice. Equine Veterinary Education 18(3):149-156.
Meuten DJ (2020). Tumors in Domestic Animals. 5th Edn, Ames, USA: John Wiley &Sons.
Nair SS, Suresh L and Vasanth MS (2013). Bovine ocular squamous cell carcinoma in working bullocks: A report of three cases. Frontier Journal of Veterinary and Animal Science 2(1):69-70.
Nylen U, Cekan E, Jonasson GB, Lewin F and Skog S (2001). Effects of 5 fluorouracil on cell cycle arrest and toxicity induced by X irradiation in normal mammalian cells. Cell Proliferation 34(2):85-98.
Olar A, Wani KM, Sulman EP, Mansouri A and Zadeh G (2015). Mitotic index is an independent predictor of recurrence free survival in meningioma. Brain Pathology 25(3):266-275.
Oral H, Beytut E, Kuru M, Karakurt E and Demir MC (2019). Perivulvar squamous cell carcinoma in a cow. Journal of the Hellenic Veterinary Medical Society 70(1):1449-1454.
Orenberg EK, Miller BH, Greenway HT, Koperski JA and Lowe N (1992). The effect of intralesional 5-fluorouracil therapeutic implant (MPI 5003) for treatment of basal cell carcinoma. Journal of the American Academy of Dermatology 27(5):723-728.
Paterson S (1997). Treatment of superficial ulcerative squamous cell carcinoma in three horses with topical 5 fluorouracil. Veterinary Record 141(24):626-628.
Patel AM, Sutaria PT, Patel JB, Patel AM and Patel PB (2019). Surgical management of perineal squamous cell carcinoma with 5-fluorouracil adjuvant therapy in sixteen mares. Journal of Pharmacognosy and Phytochemistry 8(6):2185-2187.
Paskulin GA, Gazzola Zen PR, de Camargo Pinto LL, Rosa R and Graziadio C (2005). Combined chemotherapy and teratogenicity. Birth Defects Research Part A: Clinical and Molecular Teratology 73(9):634-637.
Prasath NB, Balachandran C and Raman A (2009). Vulvar squamous cell carcinoma in a Holstein-Friesian cross-bred cow. Indian Veterinary Journal 86(4):411-412.
Priyanka N, Nagaraja BN, Nagaraju N and Manjunath DR (2021). Study on occurrence of ocular tumors in cattle. Pharma Innovation Journal 10(7):329-333.
Pucket JD and Gilmour MA (2014). Intralesional 5 fluorouracil (5 FU) for the treatment of eyelid squamous cell carcinoma in 5 horses. Equine Veterinary Education 26(6):331-335.
Pugliese M, Mazzullo G, Niutta PP and Passantino A (2014). Bovine ocular squamous cellular carcinoma: A report of cases from the Caltagirone area, Italy. Veterinary Archives 84(5):449-457.
Purohit S, Kumar Vimlesh, Sharma Prabha, Raveendra RT, Sharma Chetan, Yadav Atul, Negi Amit, Kumar Gulshan and Pandey RP (2019). Management of parotid salivary gland affections in bovines. Ruminant Science 8(2):263-267.
Ramos AT, Norte DM, Elias F and Fernandes CG (2007). Squamous cell carcinoma in cattle, sheep and horse: Study of 50 cases in south of Rio Grande do Sul. Brazilian Journal of Veterinary Research and Animal Science 44:5-13.
Reddy NVK, Reddy KJ, Mallesh P and Raju G (2017). Surgical management of recurrent squamous cell carcinoma in a cattle-A case report. Pharma Innovation 6(8):161-162.
Saifzadeh S, Pourjafar M, Naghadeh BD and Jalali FS (2007). Caudal extradural analgesia with lidocaine, xylazine, and a combination of lidocaine and xylazine in the Iranian river buffalo (Bubalus bubalis). Iranian Journal of Veterinary Surgery 2(3):7-12.
Sharda R, Sharda N and Ghosh RC (1995). Squamous cell carcinoma of eye in Jersey cows: A case report. Indian Journal of Veterinary Surgery 16(2):127.
Sharma Sonia, Dadhich Hemant, Mathur Manisha and Singh Goverdhan (2022). Leiomyosarcoma in intestines of sheep. Ruminant Science 11(2):503-504.
Singh AP, Yasin MI and Eshoue SM (1990). Incidence and surgical management of neoplasms in ruminants and equines in Iraq. Indian Journal of Veterinary Surgery 11(2):21-25.
Singh Arvind Kumar, Harish DR, Gupta Shishir Kumar, Sahoo Aditya P, Kumar Satish and Tiwari Ashok Kumar (2015). Synthesis and conformational analysis of epsilon-poly-lysine. Ruminant Science 4(2):199-203.
Singh S, Purohit S, Malik V, Yadav S, Singh RK, Gangwar NK and Pandey RP (2016). Echo-morphometric evaluation of ocular affections in murrah buffaloes: Review of 15 cases. Ruminant Science 5(1):117-122.
Smith MA, Levine DG, Getman LM, Parente EJ and Engiles JB (2009). Vulvar squamous cell carcinoma in situ within viral papillomas in an aged quarter horse mare. Equine Veterinary Education 21(1):11-16.
Uma Rani R and Pazhanivel N (2020). Surgical and clinicopathological features of bovine ocular squamous cell carcinoma. Indian Veterinary Journal 97(2):9-12.
Valenciano AC and Cowell RL (2019). Cowell and Tyler’s Diagnostic Cytology and Hematology of the Dog and Cat-E-Book. 5thEdn, Elsevier Health Sciences;.
Vara Prasad WLNV, Murthy RVS, Nasreen A, Naik SH and Sujatha K (2016). Squamous cell carcinoma in zebu cattle-A report of two cases. International Journal of Food, Agriculture and Veterinary Sciences 6(1):11-14.
Weaver AD, Jean GS and Steiner S (2005). Bovine Surgery and Lameness. 3rdEdn, NewDelhi: Blackwell Publisher. pp 65-67.
Whitaker SJ, Kirkbride P and Amott SJ (1990). A pilot study of chemo-radiotherapy in advanced carcinoma of the vulva. British Journal of Gynecology and Obstetrics 97:436-442.
Yeruham I, Perl S, Orgad U and Yakobson B (1999). Tumours of the vulva and vagina in cattle–A 10-year survey.Veterinary Journal 158(3):237-239.