57-Title: Evaluation of ropivacaine and ropivacaine-fentanyl combination for spinal anaesthesia in urolithic male goats

57-Title: Evaluation of ropivacaine and ropivacaine-fentanyl combination for spinal anaesthesia in urolithic male goats

Authors: Narendra Sahu, Surbhi Kuldeep Tyagi, Vineet Kumar, Vivak Malik, Sumiter Singh and Mukesh Shivhare

Source: Ruminant Science (2022)-11(2):527-532.

How to cite this manuscript: Sahu Narendra, Tyagi Surbhi Kuldeep, Kumar Vineet, Malik Vivak, Singh Sumiter and Shivhare Mukesh (2022). Evaluation of ropivacaine and ropivacaine-fentanyl combination for spinal anaesthesia in urolithic male goats. Ruminant Science 11(2):527-532.

Abstract

The present study was undertaken to evaluate the efficacy of subarachnoid anaesthesia and analgesic response of ropivacaine alone and in combination with fentanyl in 12 urolithic male goats. Animals were randomly divided into two groups; group I (n=6) and II (n=6), which were administered ropivacaine (@ 0.6 mg/kg b.wt.) and ropivacaine (0.3 mg/kg) plus fentanyl (0.002 mg/kg) in combination, respectively, in which tube cystostomy was done. In both groups, heart rate, respiratory rate and rectal temperature were recorded. In addition, timings of motor incoordination were recorded; extent and depth of analgesia were evaluated with the help of pin prick at tail, perineum, inguinal, thigh, digits/pedal, anterior flank, posterior flank, lower abdomen and thorax region, Anaesthetic indices like the onset of analgesia; time to recumbency; onset of recovery; duration of analgesia and time to standing were noted down. Haemato-biochemical parameters were also recorded. There was no significant difference between the values of HR, RR and RT between the two groups at different time intervals. Complete analgesia was observed in the tail, perineum, inguinal, thigh, digits/pedal, anterior flank, posterior flank and lower abdomen region, after the administration of drugs. Motor Incoordination occurred immediately after drug administration and the incoordination was significant even after 120 minute of drug administration in both groups. A faster onset of analgesia and time of recumbency was produced by group II animals. However, the duration of analgesia and standing time was higher in group I animals.

References

Ahmad R, Shukla BP and Jain R (2011). Clinicophysiological changes following epidural analgesia by bupivacaine, ropivacaine or ropivacaine-xylazine combination in goats.  Indian Journal Veterinary Surgery 21:57-58.

Amarpal, Kinjavdekar P, Aithal HP, Singh GR, Pawde AM, Singh T, Sharma A and Pratap K (2007). Comparison of two doses of ropivacaine for lumbosacral epidural analgesia in buffalo calves (Bubalus bubalis). Veterinary Record 160:766-769.

De Rossi R, Paglios RC, de Carvalho AQ, Macedo GG and Hermeto LC (2017). Fentanyl and methadone used as adjuncts to bupivacaine for lumbosacral epidural analgesia in sheep. Veterinary Record 180(4):96-96.

Duke T, Caulkett NA, Ball SD and Remedios AM (2000). Comparative analgesic and cardiopulmonary effects of bupivacaine and ropivacaine in the epidural space of the conscious dog. Veterinary Anaesthesia Analgiology 27(1):13-21.

Halonen PM, Paatero H, Hovorka J, Haasio J and Korttila K (1993). Comparison of two fentanyl doses to improve epidural anaesthesia with 0.5% bupivacaine for caesarean section. Acta Anaesthesiologica Scandinavica 37(8):774-779.

Hansen TG (2004). Ropivacaine: A pharmacological review. Expert Review of Neurotherapeutics 4:781-91.

Jones RS (2001). Epidural analgesia in the dog and cat. Veterinary Journal 161(2):123-131

Khajuria A, Fazili MR, Shah RH, Khan FA, Bhat MH, Yaqoob DH, Naykoo NA and Ganai NA (2014). Comparison of two doses of ropivacaine hydrochloride for lumbosacral epidural anaesthesia in goats undergoing laparoscopy assisted embryo transfer. Indian Scholar Research Notices Art, 8 pages

Kumari, Sharma AK, chandrakala, Sinha MP and Gupta MK (2017). Variations in the clinical and anaesthetic parameters during administration of ropivacaine and fentanyl as lumbosacral anaesthesia in goats. Journal Animal Plant Science 27(4):1167-1175.

Sekhar KC, Veena P, Kumar RV and Ramayya PJ (2020).Comparative evaluation of ropivacaine, ropivacaine dexmedetomidine and ropivacaine-clonidine combinations for epidural analgesia in cattle. Indian Journal Animal Research 54(2):202-208.

Singh K, Kinjavdekar P, Aithal HP, Gopinathan A, Singh GR, Singh T and  Pratap K (2005). Clinicophysiological and haematobiochemical effects of epidural ropivacaine in uraemic and healthy caprines. Indian Journal Veterinary Surgery 32(1):11-15.

Wang C, Chakrabarti MK and Whitwam JG (1993). Specific enhancement by fentanyl of the effects of intrathecal bupivacaine on nociceptive afferent but not on sympathetic efferent pathways in dogs.  Anesthesiology 79(4):766-73.