4-Title: Pharmacokinetics of cefquinome in Marathwadi buffalo calves
Authors: MK Patil, AP Somkuwar and PV Patil
Source: Ruminant Science (2020)-9(2):229-232.
How to cite this manuscript: Patil MK, Somkuwar AP and Patil PV (2020). Pharmacokinetics of cefquinome in Marathwadi buffalo calves. Ruminant Science 9(2):229-232.
The present experiment was performed on six healthy Marathwadi buffalo calves of either sex to study the different pharmacokinetic parameters after a single intramuscular administration of cefquinome @ 2 mg/kg body weight by microbiological assay technique. The values of Absorption half life, distribution half life, elimination half life, volume of distribution, total body clearance, AUC, AUMC, MRT and bioavailability found were 0.24±0.02 h, 0.30±0.03 h, 2.54±0.12 h, 1.85±0.17 L/kg (Vd(B)) and 1.95±0.19 L/kg (Vdss), 0.52±0.04 L/kg.h-1, 3.99 ±0.35 µg/ml.hr, 14.93±1.48 µg/ml.hr2, 3.75± 0.18 h and 165.38%, respectively. It may be concluded that the elimination half life of cefquinome was 2.54 h in buffalo calves indicating the repeating of doses at 12 to 15 h intervals in buffalo calves.
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